A PHENOTYPIC SWITCH IN PLATELETS PROMOTES DYSREGULATED PLATELET ACTIVITY IN HYPOXIC STATES
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چکیده
منابع مشابه
A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity.
Acetylation of transcriptional regulators is normally dynamically regulated by nutrient status but is often persistently elevated in nutrient-excessive obesity conditions. We investigated the functional consequences of such aberrantly elevated acetylation of the nuclear receptor FXR as a model. Proteomic studies identified K217 as the FXR acetylation site in diet-induced obese mice. In vivo stu...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2016
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(16)30600-3